Margaritis Ι. DVM, MSc, PhD. Postdoctoral researcher, Laboratory of Animal Physiology, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki | Mavrovouniotis Ι. MD, Biopathologist, PhD candidate, Free lancer, Νea Ιonia, Thessaloniki | Giannenas Ι. DVM, PhD, Associate Professor, Laboratory of Nutrition, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki | Pitaoulis Ι. Undergraduate student, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki | Rekari R. Undergraduate student, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki | Xanthopoulos A. Undergraduate student, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki | Taitzoglou I. DVM, PhD, Professor, Laboratory of Animal Physiology, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki | Zervos I. DVM, PhD, Associate Professor, Laboratory of Animal Physiology, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki
Introduction
The aim of the study was to compare two rat metabolic syndrome (MS) models. The importance and utility of such models lies in the best possible study of human MS, a syndrome that affects millions of people worldwide and is characterized by at least three of five features, namely, obesity, dyslipidemia, hyperglycaemia, insulin resistance and hypertension. The thorough study of MS can provide valuable information for its early prevention. Despite the numerous MS models, the selection criteria are not completely clear.
Materials and methods
Blood biochemical parameters were studied in 34 male albino Wistar rats aged 2 months at the onset of the experiment.
The animals were divided in 3 groups [Controls, n=8, High-fat-High-carbohydrate (HFHC), n=13 and High- carbohydrate (HC), n=13] and each group received a respective special diet for 3 months. Body weight and glucose concentration were determined monthly.
Results
HFHC Group: 15.38% (MS), 23.1% (hyperglycemia), 7.7%(dyslipidemia), 38.46% (hyperglycaemia-deslipidaemia), 15.38% (obesity-hyperglycaemia)
HC Group: 15.38% (MS), 15.38% (dyslipidaemia), 69.23% (hyperglycaemia-dyslipidaemia).
Conclusions
The percentages of MS manifestation were similar between the two models. However, in the HC group, two traits of MS (dyslipidaemia and hyperglycaemia) were detected in much higher rates, whereas one trait of MS was detected in higher rate in the HFHC group.
