Daravigka Al. Companion Animal Clinic, Unit of Medicine, School of Veterinary Medicine, Faculty of Health Science, Aristotle University of Thessaloniki
Oikonomidis I.L. DVM, PhD, DipACVP, DipECVCP, MRCVS
Konstantinidis A.O. Companion Animal Clinic, Unit of Medicine, School of Veterinary Medicine, Faculty of Health Science, Aristotle University of Thessaloniki
Dimitraki V. Companion Animal Clinic, Unit of Medicine, School of Veterinary Medicine, Faculty of Health Science, Aristotle University of Thessaloniki
Katsiampoulas El. Companion Animal Clinic, Unit of Medicine, School of Veterinary Medicine, Faculty of Health Science, Aristotle University of Thessaloniki
Soubasis N. Companion Animal Clinic, Unit of Medicine, School of Veterinary Medicine, Faculty of Health Science, Aristotle University of Thessaloniki
Introduction
Canine hyperadrenocorticism (HAC) is associated with a hypercoagulability state. The aim of this study was to investigate alterations in platelet indices in dogs with HAC, which could be associated with increased risk of thrombosis.
Materials and Methods
The medical records of a teaching hospital (2010- 2022) were retrospectively reviewed and dogs with HAC were identified. Two control groups of healthy, adult dogs (CH) and dogs with diseases other than HAC (CD) were generated. Platelet count (PLT) and mean platelet volume (MPV) values, measured with Advia 120, Siemens Healthcare Diagnostics, Deerfield, IL, USA were retrieved. Plateletcrit (PCT) was calculated as PLT x MPV / 10.000.
Results
Twenty-three dogs were induced in each group. The median (range) PLT was higher in HAC [387 (196- 911) x 103/μL] compared to CD [253 (26-754) x103/μL] (P=0.024). A significant difference was observed in median MPV between the HAC [12 (7.1- 19.6) fL] and CH [10.65 (9.1-14.0) fL] (P=0.049), and CD [12.9 (9.6-25.3) fL] and CH [10.65 (9.1-14.0) fL] (P=0.005). The median PCT was higher in HAC [0.45 (0.24-1.02 %] compared to CH [0.33 (0.22-0.89) %] (P=0.027).
Conclusions
PLT, MPV, and PCT were significantly higher in dogs with HAC compared to healthy dogs. Further studies are warranted to investigate the association between these alterations and the risk of thrombosis.
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